Sirt6 Activator could be the key to slow down ageing
If you follow longevity research, you’ve probably heard the buzz around Sirt6. Sirt6 is a cellular “guardian” linked to DNA repair, metabolism, inflammation, and overall healthspan. The big question: can we safely activate SIRT6 in humans and move the needle on biological ageing? A new mouse study suggests the answer might be “yes,” and a randomized human trial is now underway to find out. What is SIRT6 and why do longevity scientists care? SIRT6 is a NAD+-dependent enzyme that helps maintain genome stability (think DNA repair, telomere integrity, and silencing of rogue DNA elements), while also influencing glucose/lipid metabolism and inflammatory pathways. In multiple models, dialing SIRT6 up is associated with healthier ageing. In fact, genetic overexpression of SIRT6 has been shown to extend lifespan and reduce frailty...
